和歌山県立医科大学薬学部　生体機能解析学研究室

和歌山県立医科大学薬学部
生体機能解析学研究室

Department of Physiological Sciences
School of Pharmaceutical Sciences
Wakayama Medical University

English

研究業績
Publication

2024

原著論文

  • Sexually dimorphic effects of pexidartinib on nerve injury-induced neuropathic pain in mice.
    Saika F, Fukazawa Y, Hatano Y, Kishioka S, Hino Y, Hino S, Suzuki K, Kiguchi N*. (*corresponding author)　
    Glia. 2024 Apr 9. Online ahead of print. PMID: 38591338
  • Epidermal Growth Factor Suppresses the Development of GABAergic Neurons Via the Modulation of Perineuronal Net Formation in the Neocortex of Developing Rodent Brains.
    Iwakura Y, Kobayashi Y, Namba H, Nawa H, Takei N.　
    Neurochem Res. 2024 Feb 14. Online ahead of print. PMID: 38353896
  • Enhancement of haloperidol-induced catalepsy by GPR143, an L-DOPA receptor, in striatal cholinergic interneurons.
    Arai M, Suzuki E, Kitamura S, Otaki M, Kanai K, Yamasaki M, Watanabe M, Kambe Y, Murata K, Takada Y, Arisawa T, Kobayashi K, Tajika R, Miyazaki T, Yamaguchi M, Lazarus M, Hayashi Y, Itohara S, d’Exaerde AK, Nawa H, Kim R, Bito H, Momiyama T, Masukawa D, Goshima Y.　
    J Neurosci. 2024 Jan 29:e1504232024. Online ahead of print. PMID: 38286627

著書・総説

  • 痒みの特徴と末梢性調節機構.
    木口倫一.
    和歌山保険医新聞. 2024; 556.
  • 脊髄における痒みの伝達機構.
    木口倫一.
    和歌山保険医新聞. 2024; 557.

講演・シンポジウム

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2023

原著論文

  • Characterization of spinal microglial activation in a mouse model of imiquimod-induced psoriasis.
    Saika F, Fukazawa Y, Kishioka S, Kiguchi N*. (*corresponding author)　
    J Pharmacol Sci. 2023; 153(4): 183-187.
  • Functional consequences of short-term exposure to opioids versus cannabinoids in nonhuman primates.
    Ding H#, Kiguchi N#, Mabry KM, Kishioka S, Ko MC. (#equal contribution)　
    Neuropharmacology. 2023; 223: 109328. PMID: 36356937

著書・総説

  • 霊長類における痒み調節機構.
    木口倫一, 深澤洋滋.
    皮膚科. 2023; 4(3): 301-308.
  • 痒みの中枢性伝達経路と神経伝達物質.
    木口倫一, 深澤洋滋.
    Monthly Book Derma. 2023; 337: 15-23.
  • Nociceptin Receptor-Related Agonists as Safe and Non-addictive Analgesics.
    Ding H#, Kiguchi N#, Dobbins M, Romero-Sandoval EA, Kishioka S, Ko MC. (#equal contribution)　
    Drugs. 2023; 83(9): 771-793. PMID: 37209211
  • Schizophrenia Animal Modeling with Epidermal Growth Factor and Its Homologs: Their Connections to the Inflammatory Pathway and the Dopamine System.
    Sotoyama H, Namba H, Tohmi M, Nawa H*. (*corresponding author)
    Biomolecules. 2023; 13(2): 372. PMID: 36830741

講演・シンポジウム

  • アンドロゲンによる疼痛制御機構．
    木口倫一.
    第97回日本薬理学会年会, 2023年12月16日, 神戸.
  • マクロファージおよびミクログリアを標的とした神経障害性疼痛治療戦略の可能性．
    木口倫一.
    第43回日本眼薬理学会, 2023年11月11日, 札幌.
  • Bombesin-like peptides and itch transmission in primates．
    Norikazu Kiguchi.
    第32回国際痒みシンポジウム, 2023年10月14日, 東京.
  • 痒みを生じない新しい作用機序を有するオピオイド化合物の薬効評価．
    木口倫一.
    第16回日本緩和医療薬学会年会, 2023年5月27日, 神戸.
  • かゆみの伝達を担う神経基盤．
    木口倫一.
    第11回ニューロカンファレンス和歌山, 2023年1月21日, 和歌山.

2022

原著論文

  • Rapid development of motion-streak coding in the mouse visual cortex.
    Tohmi M*, Cang J. (*corresponding author)
    iScience. 2022; 26(1): 105778. PMID: 36594036
  • Cerebrocortical activation following unilateral labyrinthectomy in mice characterized by whole-brain clearing: implications for sensory reweighting.
    Kai R, Takahashi K, Tainaka K, Iwakura Y, Namba H, Saito N, Sasaoka T, Yamaguchi S, Nawa H, Horii A.
    Sci Rep. 2022; 12(1): 15424. PMID: 36104440
  • Tas2R signaling enhances mouse neutrophil migration via a ROCK-dependent pathway.
    Kobayashi D, Watarai T, Ozawa M, Kanda Y, Saika F, Kiguchi N, Takeuchi A, Ikawa M, Matsuzaki S, Katakai T.
    Front Immunol. 2022; 13: 973880. PMID: 36059440
  • Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation.
    Imado E, Sun S, Abawa AR, Tahara T, Kochi T, Huynh TNB, Asano S, Hasebe S, Nakamura Y, Hisaoka-Nakashima K, Kotake Y, Irifune M, Tsuga K, Takuma K, Morioka N, Kiguchi N, Ago Y.
    Neurochem Int. 2022; 160: 105415. PMID: 36027995
  • Increased self-triggered vocalizations in an epidermal growth factor-induced rat model for schizophrenia.
    Narihara I, Yokoyama H, Namba H, Sotoyama H, Inaba H, Kitayama E, Tamada K, Takumi T, Nawa H*. (*corresponding author)
    Sci Rep. 2022; 12(1): 12917. PMID: 35902695
  • Elevation of EGR1/zif268, a Neural Activity Marker, in the Auditory Cortex of Patients with Schizophrenia and its Animal Model.
    Iwakura Y, Kawahara-Miki R, Kida S, Sotoyama H, Gabdulkhaev R, Takahashi H, Kunii Y, Hino M, Nagaoka A, Izumi R, Shishido R, Someya T, Yabe H, Kakita A, Nawa H.
    Neurochem Res. 2022; 47(9): 2715-2727. PMID: 35469366
  • Functional roles of neuromedin B and gastrin-releasing peptide in regulating itch and pain in the spinal cord of non-human primates.
    Kiguchi N*, Ding H, Park SH, Mabry KM, Kishioka S, Shiozawa Y, Alfonso Romero-Sandoval E, Peters CM, Ko MC. (*corresponding author)
    Biochem Pharmacol. 2022; 198: 114972. PMID: 35189108
  • The dual role of dopamine in the modulation of information processing in the prefrontal cortex underlying social behavior.
    Sotoyama H, Inaba H, Iwakura Y, Namba H, Takei N, Sasaoka T, Nawa H.
    FASEB J. 2022; 36(2): e22160. PMID: 35064699
  • USP10 Inhibits Aberrant Cytoplasmic Aggregation of TDP-43 by Promoting Stress Granule Clearance.
    Takahashi M, Kitaura H, Kakita A, Kakihana T, Katsuragi Y, Onodera O, Iwakura Y, Nawa H, Komatsu M, Fujii M.
    Mol Cell Biol. 2022; 42(3): e0039321. PMID: 35007165
  • EGF Downregulates Presynaptic Maturation and Suppresses Synapse Formation In Vitro and In Vivo.
    Takei N, Yokomaku D, Yamada T, Nagano T, Kakita A, Namba H, Ushiki T, Takahashi H, Nawa H.
    Neurochem Res. 2022; 47(9): 2632-2644. PMID: 34984589
  • Rat call-evoked electrocorticographic responses and intercortical phase synchrony impaired in a cytokine-induced animal model for schizophrenia.
    Narihara I, Kitajo K, Namba H, Sotoyama H, Inaba H, Watanabe D, Nawa H*. (*corresponding author)
    Neurosci Res. 2022; 175: 62-72. PMID: 34699860

著書・総説

  • Potential therapeutic targets for the treatment of opioid abuse and pain.
    Kiguchi N*, Ko MC. (*corresponding author)
    Adv Pharmacol. 2022; 93: 335-371. PMID: 35341570
  • Therapeutic potentials of NOP and MOP receptor coactivation for the treatment of pain and opioid abuse.
    Kiguchi N*, Ding H, Ko MC. (*corresponding author)
    J Neurosci Res. 2022; 100(1): 191-202. PMID: 32255240

講演・シンポジウム

  • GRPによる霊長類のかゆみ調節機構．
    木口倫一.
    環境医学研究所・順天堂かゆみ研究センター第8回学術シンポジウム, 2022年11月26日, 東京.
  • Pitch and duration mismatch negativity of a cytokine-induced rat model for schizophrenia
    Hiroyuki Nawa.
    The 9th Mismatch Negativity conference, 2022年9月21日, Fukushima.

2021

原著論文

  • The dopamine D2 agonist quinpirole impairs frontal mismatch responses to sound frequency deviations in freely moving rats.
    Inaba H, Namba H, Kida S, Nawa H.
    Neuropsychopharmacol Rep. 2021; 41(3): 405-415. PMID: 34296531
  • Inter-breeder differences in prepulse inhibition deficits of C57BL/6J mice in a maternal immune activation model.
    Kobayashi Y, Inaba H, Iwakura Y, Namba H, Sotoyama H, Murata Y, Iwamoto K, Nawa H*. (*corresponding author)
    Neuropsychopharmacol Rep. 2021; 41(3): 416-421. PMID: 34043885
  • Functional Profile of Systemic and Intrathecal Cebranopadol in Nonhuman Primates.
    Ding H, Trapella C, Kiguchi N, Hsu FC, Caló G, Ko MC.
    Anesthesiology. 2021; 135(3): 482-493. PMID: 34237134
  • Chemogenetic activation of central gastrin-releasing peptide-expressing neurons elicits itch-related scratching behavior in male and female mice.
    Kiguchi N*, Fukazawa Y, Saika A, Uta D, Saika F, Nakamura TY, Ko MC, Kishioka S. (*corresponding author)
    Pharmacol Res Perspect. 2021; 9(3): e00790. PMID: 34000759
  • Chemogenetic Activation of CX3CR1-Expressing Spinal Microglia Using Gq-DREADD Elicits Mechanical Allodynia in Male Mice.
    Saika F, Matsuzaki S, Kishioka S, Kiguchi N*. (*corresponding author)
    Cells. 2021; 10(4): 874. PMID: 33921365
  • Resting-state dopaminergic cell firing in the ventral tegmental area negatively regulates affiliative social interactions in a developmental animal model of schizophrenia.
    Sotoyama H, Namba H, Kobayashi Y, Hasegawa T, Watanabe D, Nakatsukasa E, Sakimura K, Furuyashiki T, Nawa H*. (*corresponding author)
    Transl Psychiatry. 2021; 11(1): 236. PMID: 33888687

著書・総説

  • ノシセプチン受容体を標的とした安全なオピオイド鎮痛薬の可能性.
    木口倫一, 岸岡史郎, Mei-Chuan Ko.
    日本薬理学雑誌. 2021; 156(3): 139-144.

講演・シンポジウム

  • ミクログリアの性差と神経障害性疼痛．
    木口倫一.
    痛みの研究会2021, 2022年1月31日, オンライン開催.
  • 安全に使用できる新しいオピオイド鎮痛薬の可能性.
    木口倫一.
    第40回鎮痛薬・オピオイドペプチドシンポジウム, 2021年9月4日, オンライン開催.
  • 統合失調症に対する動物モデルの現状と課題・展望
    那波宏之.
    生体機能と創薬シンポジウム2021, 2021年8月26日, 札幌.
  • Peripheral Cytokines at Perinatal and Prenatal Stages Perturb Neurocognitive Development; Implication in Schizophrenia
    Hiroyuki Nawa.
    2021 The Uehara International Symposium, 2021年6月8日, オンライン開催.